Universiti Teknologi Malaysia Institutional Repository

PHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying : effects of processing parameters

Sultana, Naznin and Min Wang, Min Wang (2011) PHBV tissue engineering scaffolds fabricated via emulsion freezing / freeze-drying : effects of processing parameters. In: 2011 International Conference On Biomedical Engineering And Technology (ICBET 2011).

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Abstract

. Biodegradable polymers have been widely used for scaffolds in tissue engineering which aims to form completely natural tissues without leaving permanently synthetic element(s) in the human body. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a natural, biocompatible and biodegradable polymer suitable for tissue engineering applications. This paper reports the fabrication and characterization of threedimensional, highly porous PHBV scaffolds produced through the emulsion freezing/freeze-drying technique. PHBV emulsions having 2.5%, 5%, 7.5%, 10%, 12.5% (w/v) PHBV concentrations were used. Freezing and freeze-drying of polymer/solvent/water phase emulsions produced hard and tough scaffolds with interconnected pores having good handling quality. The porosity of scaffolds changed from 85% to 71% when the PHBV concentration in emulsions increased from 2.5% to 12.5%. Compressive mechanical properties of scaffolds were increased with increasing PHBV concentration. The scaffolds had pore sizes ranging from several microns to a few hundred microns.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:processing parameters
Divisions:Biosciences and Medical Engineering
ID Code:46146
Deposited By: Haliza Zainal
Deposited On:10 Jun 2015 11:01
Last Modified:29 Aug 2017 16:44

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