Protein-protein interactions mapping in the human brain diseases

Abstract

The human brain acts as the central control of the human nervous system. Environmental factors, human life styles and genetic factors are the main causes of brain diseases. Unfortunately, most of the brain diseases are still incurable because of multiple and complex reasons. Understanding the fundamental of the disorders is crucial in order to cure or treat them. Protein-protein interactions network study is used to understand the cellular operations in brain cells and there often interconnectivity between different brain diseases. A map of protein-protein interaction network that is associated with brain diseases was created with a total of 844 proteins and 903 interactions using NAViGaTOR and Cytoscape. It was discovered that 17 different brain diseases were interconnected and 61 new proteins were found to be co-expressed with 13 ―interconnector‖ proteins connecting different brain diseases. The results demonstrated that brain diseases are interconnected with each other. The network mapping also revealed the functional and physical interactions which would be very useful for prediction of new protein interactions and protein functions in drug design. It is anticipated that this study would be a reference for a future more sophisticated in vitro research into the protein-protein interactions and future drug design.