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Enantioseparation of enilconazole using cyclodextrin-modified MEKC

Hermawan, Dadan and Ahmad Kamali, Ahmad Nor Shafiq and Wan Ibrahim, Wan Aini and Sanagi, Mohd. Marsin (2011) Enantioseparation of enilconazole using cyclodextrin-modified MEKC. Journal of Fundamental Sciences, 1823-6 (7). pp. 78-81. ISSN 2289-5981

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Official URL: https://dx.doi.org/10.11113/mjfas.v7n1.241

Abstract

Enantiomeric separation of enilconazole has been successfully achieved using cyclodextrin modified micellar electrokinetic chromatography (CD-MEKC) method with HP-γ-CD as chiral selector. Two parameters which were HP-γ-CD concentration and SDS concentration have been optimized by investigating their effects on resolution and analysis time. Enantioresolution of enilconazole was achieved by the optimized CD-MEKC system containing 40 mM HP-γ-CD, 40mM SDS and 20mM phosphate buffer (pH8) with resolution (Rs=1.3) and analysis time within 9min. Good repeatabilities were obtained in term of RSD% (n=3) for migration time, peak area and peak height ranging from 0.07 to 6.1%. The optimized CD-MEKC method was a simple, less solvent used, and able to perform enantiomeric separation of enilconazole with a good resolution and relatively short analysis time.

Item Type:Article
Uncontrolled Keywords:Enantioseparationn, Enilconazole, CCD-MEKC, HP-γγ-CD
Subjects:Q Science
Divisions:Science
ID Code:39922
Deposited By: Fazli Masari
Deposited On:21 Jul 2014 13:20
Last Modified:17 Mar 2019 12:22

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