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Monitoring the effect of hypoxia in bowel dialysate metabolites levels with online biosensors

Corcoles Perpinan, Emma Paola and Boutelle, M. G. and Deeba, S. and Hanna, G. B. and Darzi, A. (2012) Monitoring the effect of hypoxia in bowel dialysate metabolites levels with online biosensors. In: 2012 International Conference on Biomedical Engineering, ICoBE 2012. IEEE, New York, USA, pp. 60-62. ISBN 978-145771989-9

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Official URL: http://dx.doi.org/10.1109/ICoBE.2012.6178955


The intestinal tract is one of the main organs that, after hemorrhage or shock, appears to be involved in an ischemic/reperfusion injury. Metabolic substances, such as glucose and lactate are useful measurements for the monitoring of intestinal ischemia, since this provokes variation of intracellular biochemical markers. In order to identify the ischemic/reperfusion mechanism adequately, physiological monitoring of the bowel under a different stress condition is required. Biomarkers were monitored during hypoxic conditions induced in a swine model to investigate the effect of this physiological variable on metabolic rates. Results showed that hypoxia could have different effects on bowel dialysate metabolites levels depending on tissue capabilities.

Item Type:Book Section
Additional Information:Indexed by Scopus
Uncontrolled Keywords:biosensors, hypoxia, intestinal microdialysis, metabolic biomarkers
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:35722
Deposited By: Fazli Masari
Deposited On:29 Oct 2013 01:10
Last Modified:02 Feb 2017 05:24

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