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Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)]

Salam, M. A. and Affan, M. A. and Ahmad, Fasihuddin and Arafath, Md. Azharul and Mohamed Tahir, M. Ibrahim and Shamsuddin, Mustaffa (2012) Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)]. Journal of Coordination Chemistry, 65 (18). pp. 3174-3187. ISSN 0095-8972

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Official URL: http://dx.doi.org/10.1080/00958972.2012.711823

Abstract

Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl 2(L)] (2), [BuSnCl 2(L)] (3), [Me 2SnCl(L)] (4), and [Ph 2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies. The molecular structure of 5 was also determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and the central tin(IV) atom is six-coordinate in distorted octahedral geometry. The ligand (1) and complexes were screened for their invitro antibacterial activities. The cytotoxic activities of 1-5 were tested against A2780 and A2780/Cp8 cancer cell lines. The compounds have better antibacterial activities than the free ligand; 2-5 are more potent cytotoxic agents than 1, while the diphenyltin(IV) 5 is more active with IC 50 values of 0.05 and 0.54molL 1 against A2780 and A2780/Cp8 cell lines, respectively.

Item Type:Article
Uncontrolled Keywords:Crystal structure, Cytotoxicity
Subjects:Q Science
Divisions:Science
ID Code:33891
Deposited By: Fazli Masari
Deposited On:30 Sep 2013 15:47
Last Modified:30 Nov 2018 14:41

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