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Swelling behaviour and controlled drug release from cross-linked kappa-carrageenan/NaCMC hydrogel by diffusion mechanism

Hezaveh, Hadi and Muhamad, Ida Idayu and Noshadi, Iman and Fen, Lim Shu and Ngadi, Norzita (2012) Swelling behaviour and controlled drug release from cross-linked kappa-carrageenan/NaCMC hydrogel by diffusion mechanism. Journal of Microencapsulation, 29 (4). pp. 368-379. ISSN 0265-2048

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Official URL: https://www.tandfonline.com/doi/abs/10.3109/026520...

Abstract

We studied a model system of controlled drug release using beta-carotene and kappa-carrageenan/NaCMC hydrogel as a drug and a device, respectively. Different concentrations of genipin were added to crosslink the beta-carotene loaded beads by using the dripping method. Results have shown that the cross-linked beads possess lower swelling ability in all pH conditions (pH 1.2 and 7.4), and swelling ratio decreases with increasing genipin concentration. Microstructure study shows that cross-linking has enhanced the stability and structure of the beads network. Determination of diffusion coefficient for the release of encapsulated beta-carotene indicates less diffusivity when beads are cross-linked. Swelling models using adaptive neuro fuzzy show that using genipin as a cross-linker in the kC/NaCMC hydrogels affects the transport mechanism. The model shows very good agreement with the experimental data that indicates that applying ANFIS modelling is an accurate, rapid and simple way to model in such a case for controlled release applications.

Item Type:Article
Uncontrolled Keywords:diffusion, microencapsulation, polymerization
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:33683
Deposited By: Fazli Masari
Deposited On:06 Sep 2013 08:45
Last Modified:14 Oct 2018 08:19

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