Using bayesian networks to construct gene regulatory networks from microarray data

Abstract

In this research, Bayesian network is proposed as the model to construct gene regulatory networks from Saccharomyces cerevisiae cell-cycle gene expression dataset and Escherichia coli dataset due to its capability of handling microarray datasets with missing values. The goal of this research is to study and to understand the framework of the Bayesian networks, and then to construct gene regulatory networks from Saccharomyces cerevisiae cell-cycle gene expression dataset and Escherichia coli dataset by developing Bayesian networks using hill-climbing algorithm and Efron’s bootstrap approach and then the performance of the constructed gene networks of Saccharomyces cerevisiae are evaluated and are compared with the previously constructed sub-networks by Dejori [14]. At the end of this research, the gene networks constructed for Saccharomyces cerevisiae not only have achieved high True Positive Rate (more than 90%), but the networks constructed also have discovered more potential interactions between genes. Therefore, it can be concluded that the performance of the gene regulatory networks constructed using Bayesian networks in this research is proved to be better because it can reveal more gene relationships.