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Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells

Jaganathan, Saravana Kumar and Supriyanto, Eko (2012) Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells. Molecules, 17 (6). pp. 6290-6304. ISSN 1420-3049


Official URL: https://www.mdpi.com/1420-3049/17/6/6290


Phenolic phytochemicals are a broad class of nutraceuticals found in plants which have been extensively researched by scientists for their health-promoting potential. One such a compound which has been comprehensively used is eugenol (4-allyl-2-methoxyphenol), which is the active component of Syzigium aromaticum (cloves). Aromatic plants like nutmeg, basil, cinnamon and bay leaves also contain eugenol. Eugenol has a wide range of applications like perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anesthetic. Increasing volumes of literature showed eugenol possesses antioxidant, antimutagenic, antigenotoxic, anti-inflammatory and anticancer properties. Molecular mechanism of eugenol-induced apoptosis in melanoma, skin tumors, osteosarcoma, leukemia, gastric and mast cells has been well documented. This review article will highlight the antiproliferative activity and molecular mechanism of the eugenol induced apoptosis against the cancer cells and animal models.

Item Type:Article
Uncontrolled Keywords:eugenol, antiproliferative, cancer, chemoprevention
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:32932
Deposited By: Fazli Masari
Deposited On:31 Jul 2013 00:52
Last Modified:31 Oct 2018 12:33

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