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Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata

Muhammad, Norhayati and Din, Laily and Sahidin, Idin and Hashim, Siti Farah and Ibrahim, Nazlina and Zakaria, Zuriati and Yaacob, Wan A. (2012) Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata. Molecules, 17 (8). pp. 9043-9055. ISSN 1420-3049 (Electronic)

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Official URL: http://dx.doi.org/10.3390/molecules17089043

Abstract

A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the ß-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC50s 0.84 to 10.06 mM) and displayed strong inhibition of ß-carotene oxidation (IC50s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC50 values between 161 to 830 µM.

Item Type:Article
Uncontrolled Keywords:Resveratrol oligomer, Shorea acuminata
Subjects:Q Science > Q Science (General)
Divisions:Malaysia-Japan International Institute of Technology
ID Code:32868
Deposited By: Fazli Masari
Deposited On:23 Jul 2013 07:52
Last Modified:30 Nov 2018 06:31

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