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Numerical solution for PDE-constrained optimization problem in cardiac electrophysiology

Kin, Wei Ng and Ahmad, Rohanin (2012) Numerical solution for PDE-constrained optimization problem in cardiac electrophysiology. International Journal of Computer Applications, 44 (12). pp. 11-15. ISSN 0975-8887

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Official URL: http://research.ijcaonline.org/volume44/number12/p...


In this paper, we present the numerical solution for the PDE-constrained optimization problem arises in cardiac electrophysiology. The monodomain model, which is a well-established model for simulating electrical behavior of the cardiac tissue, appears as the constraint in our problem. Our objective is to search for the optimal applied current, which is able to dampen out the excitation wavefront of the transmembrane potential during defibrillation process. The modified Dai-Yuan nonlinear conjugate gradient method is employed for computing the optimal applied current, and our numerical results show that the excitation wavefront is successfully dampened out by the optimal applied current.

Item Type:Article
Uncontrolled Keywords:Monodomain model, Operator splitting, Optimal control
Subjects:Q Science
ID Code:31113
Deposited By: Fazli Masari
Deposited On:05 Mar 2014 13:05
Last Modified:31 Mar 2019 16:23

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