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Synthesis of cationic porphyrins as potential gene transfection carriers

Kiew, Siaw Fui and Mohamed Zulkifli, Razauden and Bakar, Mohd. Bakri (2012) Synthesis of cationic porphyrins as potential gene transfection carriers. Malaysian Journal of Fundamental and Applied Sciences, 8 (4). pp. 203-208. ISSN 1823-626X

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Official URL: http://mjfas.ibnusina.utm.my/index.php/jfs/article...


Porphyrins are found having strong but reversible interaction with nucleic acid and thus can be used as complementary to other non-viral vectors in gene transfection delivery. Amphiphilic porphyrins with combination of hydrophobic and hydrophilic substituents along the peripheral of porphyrin macrocycle were synthesized with an attempt to facilitate the membrane penetration as well as better accumulation on the targeted cells. Besides, their fluorescent properties can be used as marker to identify their localization in the intracellular domain. Adler-Longo condensation method was employed to synthesize basic cationic porphyrins and novel asymmetrical amphiphilic cationic porphyrins. All compounds were characterized using 1H-NMR, 13C-NMR, Ultraviolet (UV) and Infrared (IR) spectroscopy.

Item Type:Article
Additional Information:UTM Open Access Journal
Uncontrolled Keywords:porphyrins, condensation, amphiphilic, vectors, gene transfection
Subjects:Q Science > Q Science (General)
Q Science > QM Human anatomy
R Medicine > R Medicine (General)
ID Code:29092
Deposited By: Maznah Mohamed Ali
Deposited On:13 Mar 2013 03:43
Last Modified:27 May 2014 04:27

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