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A continuous membrane microbioreactor system for development of integrated pectin modification and separation processes

Zainal Alam, Muhd. Nazrul Hisham and Pinelo, Manuel and Samanta, Kama and Jonsson, Gunnar and Meyer, Anne and Gernaey, Krist V. (2011) A continuous membrane microbioreactor system for development of integrated pectin modification and separation processes. Chemical Engineering Journal, 167 (2-3). pp. 418-426. ISSN 1385-8947

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Official URL: http://dx.doi.org/10.1016/j.cej.2010.09.082


Evaluation of novel enzyme reactions and reactor systems is often hampered by costs related to obtaining sufficient amounts of enzymes. In this respect, it will be advantageous to assess new enzymatic processes in microbioreactors designed to resemble genuine reactor systems. In this work, we present a continuous membrane microbioreactor prototype for development of enzyme catalyzed degradation of pectin. Membrane reactors are becoming increasingly important for the novel 'biorefining' type of processes that either require product removal to avoid product inhibition or rest on partial hydrolysis of the substrate to obtain e.g. value-added oligosaccharides from complex biopolymers. The microbioreactor prototype was fabricated from poly(methylmethacrylate) (PMMA) and poly(dimethylsiloxane) (PDMS) and designed as a loop reactor (working volume approximately 190. µL) integrated with a regenerated cellulose membrane for separation of low molecular weight products. The main technical considerations and challenges related to establishing the continuous membrane microbioreactor are discussed. The workability of the prototype was validated by comparing the process data at microscale to those obtained using a lab-scale membrane reactor system. The prototype presented here is easy to handle, has a low complexity - thus a relatively simple fabrication process - and can be used to study extended enzymatic reactions.

Item Type:Article
Uncontrolled Keywords:Microbioreactor, continuous, membrane separation, scale down, pectin hydrolysis
Subjects:Q Science > QD Chemistry
Divisions:Chemical and Natural Resources Engineering
ID Code:28572
Deposited By: Yanti Mohd Shah
Deposited On:22 Oct 2012 10:19
Last Modified:30 Nov 2018 07:07

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