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Kinetic and reactor modelling of lipases catalyzed (R,S)-1-phenylethanol resolution

Lee Suan, Chua and Kian Kai, Cheng and Chew Tin, Lee and Sarmid, Mohamad Roji (2010) Kinetic and reactor modelling of lipases catalyzed (R,S)-1-phenylethanol resolution. Iranica Journal of Energy and Environment, 1 (3). pp. 234-245. ISSN 2079-2115

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This study was focused on the development of a kinetic model and a reactor model for the enzymatic resolution of (R,S)-1-phenylethanol. The reaction progress curves catalyzed by immobilized lipases, ChiroCLEC-PC in batch stirred tank reactor were used to develop the kinetic model. The resolution followed Ping-Pong Bi-Bi mechanism with the inhibition of lauric acid, (R,S)-1-phenylethanol and water. The validity of the model was verified by fitting it to another experimental data catalyzed by immobilized lipases, Chirazyme L2, c.-f., C3, lyo at the same reaction conditions. The rate equation was then applied for the development of reactor model in a recirculated packed bed reactor system. The overall effectiveness factor and Peclet number were used to determine the mass transfer and axial dispersion limitation in the reactor performance. The reactor model was verified by fitting it to the larger scale reactor data with the correlation coefficient value more than 0.99.

Item Type:Article
Subjects:Q Science > QD Chemistry
Divisions:Chemical and Natural Resources Engineering
ID Code:25928
Deposited By: Liza Porijo
Deposited On:18 Jun 2012 01:48
Last Modified:13 Oct 2017 12:27

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