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Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

Jantan, Ibrahim and Mohd. Yasin, Yusyila Harlina and Jamil, Shajarahtunnur and Mohd. Sirat, Hasnah and Basar, Norazah (2010) Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood. Journal of Natural Medicines, 64 (3). pp. 365-369. ISSN 1340-3443

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Official URL: http://dx.doi.org/10.1007/s11418-010-0410-0

Abstract

Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC50 value of 100.9 lM. It also showed strong inhibition against ADP-induced aggregation, with an IC50 value of 57.1 lM. Isobavachalcone, 20,40-dihydroxy-4-methoxy-30-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC50 values ranging from 55.3 to 192.0 lM, but did not show such effect against other inducers.

Item Type:Article
Uncontrolled Keywords:2′,4′-dihydroxy-4-methoxy-3′- prenyldihydrochalcone; Antiplatelet aggregation; Arachidonic acid; Artocarpus species; Cycloheterophyllin; Human whole blood
Subjects:Unspecified
Divisions:Science
ID Code:23061
Deposited By: Kamariah Mohamed Jong
Deposited On:30 Apr 2012 17:02
Last Modified:04 May 2017 12:42

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