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Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin

Ibrahim, W. A. W. and Hermawan, Dadan and Sanagi, M. M. (2010) Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin. Journal of Pharmaceutical and Biomedical Analysis, 53 (5). 1244 - 1249.

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Official URL: http://dx.doi.org/10.1007/978-1-62703-263-6_22

Abstract

The separation of enantiomers is one of the important fi elds of modern analytical chemistry, especially for agrochemical and pharmaceutical products because the stereochemistry has a signi fi cant in fl uence on the biological activities of compounds. Cyclodextrin-modi fi ed micellar electrokinetic chromatography (CD-MEKC) has become an important capillary electrophoresis mode for enantioseparations. Here, we describe an example of a CD-MEKC method using hydroxypropyl- ? -cyclodextrin as chiral selector and sodium dodecyl sulfate as micellar solution for enantioseparation of triazole fungicides and the drug econazole.

Item Type:Article
Uncontrolled Keywords:chromatography, electrophoresis, econazole
Subjects:Q Science > Q Science (General)
Divisions:Science
ID Code:22959
Deposited By: Narimah Nawil
Deposited On:26 Feb 2017 11:16
Last Modified:21 Oct 2018 12:29

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