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A novel method for the production of crystalline micronised particles

Syed Muhammad, Syed Anuar and Langrish, Tim Alan Granville and Tang, Patricia and Adi, Handoko and Chan, Hakkim and Kazarian, Sergei and Dehghani, Fariba (2010) A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388 (1-2). 114 - 122. ISSN 0378-5173

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Official URL: https://doi.org/10.1016/j.ijpharm.2009.12.047

Abstract

The aim of this study was to develop a method for converting an amorphous drug to a crystalline form to enhance its stability and inhalation performance. Spray-dried amorphous salbutamol sulphate powder was conditioned with supercritical carbon dioxide (scCO2) modified with menthol. The effect of menthol concentration, pressure, temperature and time on the characteristics of the resulting salbutamol sulphate powder was investigated. Pure scCO2 had no effect on the physical properties of amorphous salbutamol sulphate; however, scCO2 modified with menthol at 150 bar and 50 °C was efficient in converting amorphous drug to crystalline form after 12 h of conditioning. The average particle size of powders decreased slightly after the conditioning process because of reducing agglomeration between particles by increasing surface roughness. Emitted dose measured by the fine particle fraction (FPFemitted) of amorphous salbutamol sulphate was enhanced from 32% to 43% after conditioning with scCO2 + menthol and its water uptake was significantly decreased. This study demonstrates the potential of scCO2 + menthol for converting amorphous forms of powders to crystalline, while preserving the particle size.

Item Type:Article
Uncontrolled Keywords:salbutamol sulphate, menthol, crystallisation
Subjects:Q Science > QD Chemistry
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:22817
Deposited By: Narimah Nawil
Deposited On:02 Sep 2017 15:34
Last Modified:21 Oct 2018 12:29

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