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Recent progress in polymeric non-invasive insulin delivery

Sabbagh, Farzaneh and Muhamad, Ida Idayu and Niazmand, Razieh and Dikshit, Pritam Kumar and Kim, Beom Soo (2022) Recent progress in polymeric non-invasive insulin delivery. International Journal of Biological Macromolecules, 203 (-). pp. 222-243. ISSN 0141-8130 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.ijbiomac.2022.01.134

Abstract

The design of carriers for insulin delivery has recently attracted major research attentions in the biomedical field. In general, the release of drug from polymers is driven via a variety of polymers. Several mechanisms such as matrix release, leaching of drug, swelling, and diffusion are usually adopted for the release of drug through polymers. Insulin is one of the most predominant therapeutic drugs for the treatment of both diabetes mellitus; type-I (insulin-dependent) and type II (insulin-independent). Currently, insulin is administered subcutaneously, which makes the patient feel discomfort, pain, hyperinsulinemia, allergic responses, lipodystrophy surrounding the injection area, and occurrence of miscarried glycemic control. Therefore, significant research interest has been focused on designing and developing new insulin delivery technologies to control blood glucose levels and time, which can enhance the patient compliance simultaneously through alternative routes as non-invasive insulin delivery. The aim of this review is to emphasize various non-invasive insulin delivery mechanisms including oral, transdermal, rectal, vaginal, ocular, and nasal. In addition, this review highlights different smart stimuli-responsive insulin delivery systems including glucose, pH, enzymes, near-infrared, ultrasound, magnetic and electric fields, and the application of various polymers as insulin carriers. Finally, the advantages, limitations, and the effect of each non-invasive route on insulin delivery are discussed in detail.

Item Type:Article
Uncontrolled Keywords:insulin delivery, nasal, ocular, oral
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:100942
Deposited By: Narimah Nawil
Deposited On:18 May 2023 04:36
Last Modified:18 May 2023 04:36

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