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Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor

Abd. Aziz, Azila (2009) Quantitative analysis of performance of a hydrogen peroxide-based glucose biosensor. Jurnal Teknologi (Kejuruteraan) (51F). pp. 96-106. ISSN 0127-9696

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Official URL: http://www.penerbit.utm.my/onlinejournal/51/F/51si...

Abstract

A partial glucose biosensor was constructed using a selective internal layer, an enzyme layer and a gold electrode. Both membrane layers are based on cross-linked polyvinyl alcohol (PVA). The performance of the partial glucose biosensor was analyzed particularly with respect to the interfering effects of acetaminophen, a non-ionic molecule. The sensitivity of the immobilized enzyme to glucose was high but it was not high enough to counter acetaminophen interference. The addition of the moderately selective PVA internal layer did not seem to have a significant effect on interference. A mathematical model was then used to analyze the performance of a completed biosensor. A simulated external layer was added to the two layers. The mathematical model predicted that the addition of an external layer with lowered permeability to solutes could improve the performance of the sensor.

Item Type:Article
Uncontrolled Keywords:Glucose biosensor; mathematical modeling; acetaminophen; electrochemical interference; cross-linked polyvinyl alcohol
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:9996
Deposited By: Pn Norhayati Abu Ruddin
Deposited On:16 Jul 2010 04:25
Last Modified:22 Jul 2010 02:03

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