Design of experiment of redispersible spray dried powder of fatty acid-nanostructured lipid carriers using a 23 full factorial design

Abstract

Fatty acid such as lauric and oleic acid have been used extensively either in cosmeceutical or pharmaceutical products as an emollient or moisturiser. In this study, fatty acids which combine lauric and oleic acids have been formulated into nanostructured lipid carriers (FA-NLCs) system in order to improve its physical stability hence, enhancing the topical effectiveness. In order to prolong the stability of the FA-NLCs, spray drying technique has been applied to produce FA-NLCs in a powder form. The current work describes the design of experiment of spray dried lipid-based nanosystems with the ability to acquire nanosystems after redispersion. FA-NLCs were prepared using melt-dispersion ultrasonication method. Three parameters were optimised with respect to spray drying; inlet temperature, flow rate and feed concentration using 23 Full Factorial Design. The responses evaluated were the powder yield, moisture content and size of the redispersed nanoaggregates. Results showed that in achieving small redispersed nanoaggregates size, high powder yield and low moisture content was come from formulation Standard Order No 6 (Run Order No 8). In conclusion, a spray dried FA-NLCs was successfully prepared with the smallest redispersed nanoaggregate size, highest powder yield and low moisture content, potentially suitable to be used as cosmetic ingredients.