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Improved bacteriostatic and anticorrosion effects of polycaprolactone/chitosan coated magnesium via incorporation of zinc oxide

Bakhsheshi-Rad, Hamid Reza and Hamzah, Esah and Wong, See Ying and Razzaghi, Mahmood and Sharif, Safian and Ismail, Ahmad Fauzi and Berto, Filippo (2021) Improved bacteriostatic and anticorrosion effects of polycaprolactone/chitosan coated magnesium via incorporation of zinc oxide. Materials, 14 (8). pp. 1-15. ISSN 1996-1944

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Official URL: http://dx.doi.org/10.3390/ma14081930

Abstract

Magnesium has been recognized as a groundbreaking biodegradable biomaterial for implant applications, but its use is limited because it degrades too quickly in physiological solutions. This paper describes the research on the influence of polycaprolactone (PCL)/chitosan (CS)/zinc oxide (ZnO) composite coating (PCL/CS/ZnO) on the corrosion resistance and antibacterial activity of magnesium. The PCL/CS film presented a porous structure with thickness of about 40–50 μm, while after incorporation of ZnO into the PCL/CS, a homogenous film without pores and defects was attained. The ZnO embedded in PCL/CS enhanced corrosion resistance by preventing corrosive ions diffusion in the magnesium substrate. The corrosion, antibacterial, and cell interaction mechanism of the PCL/CS/ZnO composite coating is discussed in this study. In vitro cell culture revealed that the PCL/CS coating with low loaded ZnO significantly improved cytocompatibility, but coatings with high loaded ZnO were able to induce some cytotoxicity osteoblastic cells. It was also found that enhanced antibacterial activity of the PCL/CS/ZnO coating against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, while less significant antibacterial activity was detected for uncoated Mg and PCL/CS coating. Based on the results, the PCL/CS coatings loaded with low ZnO content may be recommended as a candidate material for biodegradable Mg‐based orthopedic implant applications.

Item Type:Article
Uncontrolled Keywords:antibacterial activity biocompatibility, corrosion resistance
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:94265
Deposited By: Yanti Mohd Shah
Deposited On:31 Mar 2022 15:26
Last Modified:31 Mar 2022 15:26

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