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Development of polymeric nanocomposite (xyloglucan-co-methacrylic acid/hydroxyapatite/sio2) scaffold for bone tissue engineering applications-in-vitro antibacterial, cytotoxicity and cell culture evaluation

Aslam Khan, M. U. and Mehboob, H. and Abd. Razak, S. I. and Yahya, M. Y. and Mohd. Yusof, A. H. and Ramlee, M. H. and Anand, T. J. S. and Hassan, R. and Aziz, A. and Amin, R. (2020) Development of polymeric nanocomposite (xyloglucan-co-methacrylic acid/hydroxyapatite/sio2) scaffold for bone tissue engineering applications-in-vitro antibacterial, cytotoxicity and cell culture evaluation. Polymers, 12 (6). p. 1238. ISSN 2073-4360

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Official URL: https://doi.org/10.3390/polym12061238

Abstract

Advancement and innovation in bone regeneration, specifically polymeric composite scaffolds, are of high significance for the treatment of bone defects. Xyloglucan (XG) is a polysaccharide biopolymer having a wide variety of regenerative tissue therapeutic applications due to its biocompatibility, in-vitro degradation and cytocompatibility. Current research is focused on the fabrication of polymeric bioactive scaffolds by freeze drying method for nanocomposite materials. The nanocomposite materials have been synthesized from free radical polymerization using n-SiO2 and n-HAp XG and Methacrylic acid (MAAc). Functional group analysis, crystallinity and surface morphology were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM) techniques, respectively. These bioactive polymeric scaffolds presented interconnected and well-organized porous morphology, controlled precisely by substantial ratios of n-SiO2. The swelling analysis was also performed in different media at varying temperatures (27, 37 and 47 °C) and the mechanical behavior of the dried scaffolds is also investigated. Antibacterial activities of these scaffolds were conducted against pathogenic gram-positive and gram-negative bacteria. Besides, the biological behavior of these scaffolds was evaluated by the Neutral Red dye assay against the MC3T3-E1 cell line. The scaffolds showed interesting properties for bone tissue engineering, including porosity with substantial mechanical strength, biodegradability, biocompatibility and cytocompatibility behavior. The reported polymeric bioactive scaffolds can be aspirant biomaterials for bone tissue engineering to regenerate defecated bone.

Item Type:Article
Uncontrolled Keywords:antibacterial active, biocompatibility, nanotechnology
Subjects:Q Science > Q Science (General)
Divisions:Biosciences and Medical Engineering
ID Code:93891
Deposited By: Narimah Nawil
Deposited On:31 Jan 2022 08:40
Last Modified:31 Jan 2022 08:40

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