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GLUCOSE UPTAKE :Stimulatory Activity of Gynura procumbens in 3T3- F442A adipocytes

Mohd Bohari, Siti Pauliena and Hamid, Muhajir and Shaari, Khozirah and Lajis, Nordin (2006) GLUCOSE UPTAKE :Stimulatory Activity of Gynura procumbens in 3T3- F442A adipocytes. In: Malaysian Medicinal Plant: Chemistry and Biological Activity. UNIMAS and Malaysian Natural Products Society, Sarawak. ISBN 983-9257-7

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Abstract

Gynura procumbens (Compositae) has been used as folk remedy for the treatment to control diabetes mellitus and hyperlipidemia. The aim of this study was to examine whether G. procumbens extract for various solvent system had an enhancing effect on glucose uptake in 3T3 adipocyte cell lines. At the concentration 0.1mg/mL of hexane fraction showed increase in glucose uptake activity 4.5 fold whereas etyl acetate fraction increased 2.2 fold at 0.005 mg/mL of compare to untreated. For butanol fraction showed dependent manner of insulin and at 0.05mg/mL of extract, glucose uptake activity was increased 1.4 fold compare to the insulin.These results suggest that the antidiabetic action of G. procumbens may be mediated throught the stimulation of glucose uptake and the potentiation of insulin action.

Item Type:Book Section
Subjects:R Medicine > RM Therapeutics. Pharmacology
Divisions:Science
ID Code:921
Deposited By: Prof Dr. Noor Aini Abdul Rashid
Deposited On:23 Feb 2007 09:16
Last Modified:01 Jun 2010 02:49

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