Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch

Abstract

Transdermal drugs delivery offers many advantages over conventional routes of drug delivery that led to this burgeoning interest in this route in recent years. The aim of this work is to investigate the influence of diclofenac sodium (DS) loaded dual layer PVA patch on physicochemical and mechanical properties. The influence of DS-loaded dual layer PVA patch was employed and characterized using Scanning Electron Microscopy (SEM) to observe the polymeric interaction between PVA cryogel and electrospun nanofiber, the FTIR were used to study the interaction of DS in dual layer PVA patch and tensile strength were tested to study the mechanical properties of the DS-loaded dual layer PVA patch. The results show the polymer interaction between PVA cryogel and electrospun nanofiber were observed. The DS spectra were found separately from PVA matrix. As for mechanical strength the curves of DS-loaded were decreased as the percentage of DS loading increases. These results shows that the dual layer PVA patch can be used as the carrier for transdermal DS delivery.