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Electrophoretic separation of chiral agrochemicals using neutral cyclodextrin based dual selector system

UNSPECIFIED (2009) Electrophoretic separation of chiral agrochemicals using neutral cyclodextrin based dual selector system. In: UNSPECIFIED, (ed.) Proceedings of Second International Conference and Workshops on Basic and Applied Sciences & Regional Annual Fundamental Science Seminar 2009. Faculty of Science, Universiti Teknologi Malaysia. ISBN 978‐983‐9805‐73‐4

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Abstract

The enantiomeric separation of chiral agrochemicals was investigated using dual systems with mixtures of cyclodextrin derivatives. The dual cyclodextrin systems consist of two neutral cyclodextrin, namely hydroxypropyl- γ-cyclodextrin (HP-γ-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD). The agrochemicals used were three triazole fungicides viz. cyproconazole, bromuconazole and diniconazole, each with 2, 2 and 1 stereogenic centre respectively. Results showed that dual CD systems are useful to achieve and to optimize chiral separations of compounds not sufficiently separated with single CD alone. The best dual chiral recognition mode for the complete and simultaneous separation of propiconazole, bromuconazole, and diniconazole enantiomers was achieved with a mixture of 27 mM HP-β-CD and 3 mM HP-γ-CD at pH 3.0 in the phosphate buffer containing 40 mM sodium dodecyl sulfate (SDS) and 10%:5% v/v methanol : acetonitrile as organic modifiers.

Item Type:Book Section
Uncontrolled Keywords:Chiral agrochemicals, cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC), dual cyclodextrin, enantioseparation, triazole fungicides.
Divisions:Science
ID Code:9018
Deposited By: Dr Siew Ling Lee
Deposited On:30 Jun 2009 07:33
Last Modified:04 May 2012 07:02

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