Amr, A. E. and Elsayed, E. A. and Al-Omar, M. A. and El-Enshasy, H. A. (2020) Investigation of growth inhibitory effects of cyclo (n∝ -pyrido)-bis-[(l-valinyl)-lornthenyl acid hydrazide] on various cancer cells as well as in vitro vegfr-2 kinase inhibition. Journal of Scientific and Industrial Research, 79 (4). pp. 328-332. ISSN 0022-4456
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Official URL: http://nopr.niscair.res.in/handle/123456789/54367
Abstract
During the current work, we synthesized a new peptide derivative; 4,13-diisopropyl-2,5,12,15-tetraoxo-3,6,11,14-tetraaza-1(3,5)-pyridinacyclopentadecaphane-7-carbohydrazide. The prepared hydrazide was investigated for its in vivo as well as in vitro anticancer effects. Results revealed that this derivative has a great potential against 6 cancerous cell lines. Furthermore, the highest effect was obtained against HT1080 and HeLa cells, where the compound showed 7.4- and 15.1-folds increased activity against them, respectively. Additionally, the compound seems to exert its potential anticancer effect by affecting the kinase enzyme VEGFR-2. Finally, the compound showed promising results when tested in in vivo against prostate cancer developed animal models.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | azide method, macrocyclic tripeptidopyridine, cell lines |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Science |
| ID Code: | 87741 |
| Deposited By: | Narimah Nawil |
| Deposited On: | 30 Nov 2020 13:15 |
| Last Modified: | 30 Nov 2020 13:15 |
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