Bakhsheshi Rad, H. R. and Chen, X. B. and Ismail, A. F. and Aziz, M. and Hamzah, E. and Najafinezhad, A. (2019) A new multifunctional monticellite-ciprofloxacin scaffold: preparation, bioactivity, biocompatibility, and antibacterial properties. Materials Chemistry and Physics, 222 . pp. 118-131. ISSN 0254-0584
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Official URL: http://dx.doi.org/10.1016/j.matchemphys.2018.09.05...
Abstract
This work prepared novel monticellite-ciprofloxacin (Mon-CPFX) scaffolds with different concentrations of CPFX (0, 1, 3, and 6%) via the space holder method. The Mon-CPFX scaffolds had a compressive strength of 1 ± 0.1 MPa, porosity of 81–83%, and pore size of 300–420 μm. The formation of hydroxyapatite on the Mon-CPFX scaffold surfaces was observed after soaking in simulated body fluid (SBF) solution for 28 d, with a Ca/P atomic ratio of 1.62 indicating high apatite formation ability. Antibacterial tests indicated the antibacterial effect of Mon-CPFX scaffolds is strongly related to the CPFX concentration; the greatest bacterial inhibition was observed for the scaffold containing 6% CPFX. Furthermore, an MTT assay illustrated that Mon scaffold loading with up to 3% CPFX resulted in higher cell viability, cell proliferation, and attachment than for scaffolds containing 6% CPFX. This particular novel type of multifunctional Mon-CPFX scaffold could be considered for bone infection treatment owing to its suitable compressive strength along with excellent bioactivity, antibacterial performance, and biocompatibility.
Item Type: | Article |
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Uncontrolled Keywords: | biocompatibility, monticellite scaffold, space holder |
Subjects: | T Technology > TJ Mechanical engineering and machinery |
Divisions: | Mechanical Engineering |
ID Code: | 87594 |
Deposited By: | Yanti Mohd Shah |
Deposited On: | 30 Nov 2020 09:04 |
Last Modified: | 30 Nov 2020 09:04 |
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