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Response surface methodology approach to study the influence of PEG and water in cellulose acetate dialysis membranes

Idris, Ani and Lee, Kuan Yet and Noordin, M. Y. and Chan, Mieow Kee (2008) Response surface methodology approach to study the influence of PEG and water in cellulose acetate dialysis membranes. Jurnal Teknologi F (49F). pp. 39-49. ISSN 0127-9696

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Abstract

Flat sheet asymmetric dialysis membranes were fabricated using phase inversion method from polymer solution consisting of cellulose acetate, acetic acid, polyethylene glycol (PEG) and distilled water. The effect of acetic acid/PEG ratio and the distilled water content in the dialysis membrane were being investigated with respect to the urea clearance performance. Response surface methodology (RSM) was used to design the experiments and analysed the results obtained. The analysis revealed that the significant factor that affects the cellulose acetate dialysis membrane performance in terms of urea clearance is the ratio of acetic acid/PEG. Dialysis membrane with higher ratio of acetic acid/PEG gives higher urea clearance percentage due to the formation of finger like macrovoids. The relation between the urea clearance and the ratio of acetic acid/PEG in the given range of 4 – 14, was a quadratic model and the mathematical model suggested could adequately describe the performance indicators within the limits mentioned.

Item Type:Article
Uncontrolled Keywords:Dialysis membrane; RSM; water content; acetic acid/PEG ratio; urea clearance
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:8509
Deposited By: Pn Norhayati Abu Ruddin
Deposited On:28 Apr 2009 08:04
Last Modified:14 Oct 2010 04:47

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