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Simulation and sensitivity analysis on the parameter of non-targeted irradiation effects model

Nasir, Muhamad Hanis and Mohd. Siam, Fuaada (2018) Simulation and sensitivity analysis on the parameter of non-targeted irradiation effects model. Jurnal Teknologi, 8 (1). pp. 133-142. ISSN 2180-3722

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Official URL: https://dx.doi.org/10.11113/jt.v81.12448

Abstract

Real-life situations showed damage effects on non-targeted cells located in the vicinity of an irradiation region, due to danger signal molecules released by the targeted cells. This effect is widely known as radiation-induced bystander effects (RIBE). The purpose of this paper is to model the interaction of non-targeted cells towards bystander factors released by the irradiated cells by using a system of structured ordinary differential equations. The mathematical model and its simulations are presented in this paper. In the model, the cells are grouped based on the number of double-strand breaks (DSBs) and mis-repair DSBs because the DSBs are formed in non-targeted cells. After performing the model's simulations, the analysis continued with sensitivity analysis. Sensitivity analysis will determine which parameter in the model is the most sensitive to the survival fraction of non-targeted cells. The proposed mathematical model can explain the survival fraction of non-targeted cells affected by the bystander factors.

Item Type:Article
Uncontrolled Keywords:Bystander effects, double-strand breaks, survival fraction, sensitivity analysis, structured ordinary differential equation
Subjects:Q Science > QA Mathematics
Divisions:Science
ID Code:84724
Deposited By: Fazli Masari
Deposited On:29 Feb 2020 13:48
Last Modified:29 Feb 2020 13:48

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