Chemical composition of eurycoma longifolia (Tongkat Ali) and the quality control of its herbal medicinal products

Abstract

Eurycoma longifolia which is known as Tongkat Ali is commonly found in Asian countries such as Malaysia, Indonesia, Thailand, Myanmar and Cambodia. This plant is famously known for its various pharmacological activities. The plant is also reported to consist of various types of important bioactive compounds such as quassinoids, canthine-6-one alkaloids, triterpenes, squalene derivatives, $-carboline alkaloids etc which are mostly found in the root part. The presence of these important phytochemicals contributes to their different types of therapeutic effects more especially in terms of aphrodisiac properties which have resulted in a massive increase in demand and production of their Herbal Medicinal Products (HMP). These situations have resulted in the production of E. longifolia HMPs whose quality are questionable, which might be as a result of restricted of sources that might lead to some unethical activities carried out by suppliers and manufacturers in order to gain more profit. Therefore, this review focused on adulteration issues such as contamination and substitution of E. longifolia HMP. The review also includes the possible solutions on how to improve the quality of these HMP so as they can be safe for consumption. Embracing pharmacovigilance in the preparation of the HMP, proper implementation of agricultural practices such as Good Agricultural and Collection Practices (GACP) and Good Manufacturing Practices (GMP) together with the establishment of effective regulatory bodies would undoubtedly improve the quality of E. longifolia HMP sold in the market. The detailed knowledge about the main composition of the E. longifolia HMP will help to ascertain their quality, efficacy and safety as these are very important toward quality control.