β-Cyclodextrin modified PES hollow fiber membrane, a new strategy for bilirubin separation

Abstract

The aim of this study was to synthesis and evaluates the capability of modified polyethersulfone (PES) hollow fiber membrane for bilirubin separation from patients’ blood. Cyclodextrin (CD) was grafted on the membrane surface via ester bond between hydroxyl groups in CD and sulfonate functional groups on the membrane surface. Surface modification not only improved the membrane hydrophilicity, but also inhibited bovine serum albumin (BSA) and platelets adhesion on the surface. Moreover, the modified membrane could adsorb bilirubin up to 51 mg/g membrane. In conclusion, the proposed system could be a promising candidate to be used instead of resins in hemoperfusion column.