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Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)]

Affan, Md. Abu and Foo, Siong Wan and Ngaini, Zainab and Shamsuddin, Mustaffa (2009) Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)]. The Malaysian Journal of Analytical Sciences, 13 (1). pp. 63-72. ISSN 1394-2506

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Official URL: http://www.ukm.my/mjas/v13_n1/affan1.pdf

Abstract

Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R = Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized by direct reaction of thiosemicarbazone ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. These organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV-visible, FTIR, 1 H and 13C NMR spectral studies. Among them, dimethyltin(IV) complex (2) was also characterized by X-ray crystallography diffraction analyses. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-7) were determined by Artemia salina, shrimp test lethality bioassay

Item Type:Article
Uncontrolled Keywords:Thiosemicarbazone, Organotin(IV) complexes, Cytotoxicity
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:819
Deposited By: Ms Halimah Baki
Deposited On:19 Nov 2012 07:31
Last Modified:17 Feb 2017 00:16

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