Antidandruff potential of Kaempheria galanga ethanolic extracts for hair cream formulation

Abstract

The evaluation of Kaempferia galanga, Citrus hystrix and Cinnamomum zeylanicum ethanolic extracts on antifungal activities and zone of inhibition were conducted. The yield for K. galanga, C. hystrix and C. zeylanicum were 0.4, 0.7 and 0.43% of raw dried samples respectively. All the extracts demonstrated 5 mg/mL MIC with C. zeylanicum, K. galanga and C. hystrix average holozones diameter of 14.5 ± 3.8, 12.0 ± 1.8 and 12.0 ± 0.8 mm after 3 days of incubation respectively with no effect on negative control. On the other hand, Zinc Pyrithione being more potent than imidazaole as a positive control with inhibition of 32.8 ± 2.2 and 21.8 ± 3.4 respectively. Based on the findings, the anti-fungal hair cream containing K. galanga ethanolic extract was formulated into oil-in-water cream and the physicochemical properties were evaluated. The cream demonstrated desirable characteristic with no separation between oil and water after vigorously shaken at 14,600 rpm for half an hour. Furthermore the viscosity and pH were 543.7 ± 19.2 and 5.46 ± 0.01 respectively. In conclusion, K galanga ethanolic extract has a potential to be used as an anti-fungal oil in water cream formulation.