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Finite element analysis of single cell stiffness measurements using PZT-integrated buckling nanoneedles

Rad, Maryam Alsadat and Tijjani, Auwal Shehu and Ahmad, Mohd Ridzuan and Auwal, Shehu Muhammad (2016) Finite element analysis of single cell stiffness measurements using PZT-integrated buckling nanoneedles. SENSORS, 17 (1). pp. 1-17. ISSN 1424-8220

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Official URL: http://www.mdpi.com/1424-8220/17/1/14

Abstract

This paper proposes a new technique for real-time single cell stiffness measurement using lead zirconate titanate (PZT)-integrated buckling nanoneedles. The PZT and the buckling part of the nanoneedle have been modelled and validated using the ABAQUS software. The two parts are integrated together to function as a single unit. After calibration, the stiffness, Young’s modulus, Poisson’s ratio and sensitivity of the PZT-integrated buckling nanoneedle have been determined to be 0.7100 N·m-1, 123.4700 GPa, 0.3000 and 0.0693 V·m·N-1, respectively. Three Saccharomyces cerevisiae cells have been modelled and validated based on compression tests. The average global stiffness and Young’s modulus of the cells are determined to be 10.8867 ± 0.0094N·m-1 and 110.7033 ± 0.0081 MPa, respectively. The nanoneedle and the cell have been assembled to measure the local stiffness of the single Saccharomyces cerevisiae cells The local stiffness, Young’s modulus and PZT output voltage of the three different size Saccharomyces cerevisiae have been determined at different environmental conditions. We investigated that, at low temperature the stiffness value is low to adapt to the change in the environmental condition. As a result, Saccharomyces cerevisiae becomes vulnerable to viral and bacterial attacks. Therefore, the proposed technique will serve as a quick and accurate process to diagnose diseases at early stage in a cell for effective treatment.

Item Type:Article
Uncontrolled Keywords:global stiffness, local stiffness, buckling nanoneedle, PZT-integrated, single cell analysis
Subjects:T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:Electrical Engineering
ID Code:77577
Deposited By: Widya Wahid
Deposited On:27 Sep 2018 04:14
Last Modified:09 Sep 2020 06:42

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