Liposome as transdermal carrier for labisia pumila and ficus deltoidea water extracts

Abstract

In this study, liposome has been investigated as the potential transdermal carrier for Labisia pumila (Lp) and Ficus deltoidea (Fd). The encapsulation efficiency, zeta potential, particle size and transdermal transport properties of the herbal extracts loaded liposomes were determined to characterize the delivery system. The entrapment efficiency for Lipo-Lp and Lipo-Fd were 35.47 ± 2.71% and 31.23 ± 7.65%, respectively. The average diameter were153.35nm and 131.9nm, respectively and the zeta potential were -47.2 and -46.8, respectively. The permeability and partition coefficient (K) of Lipo-Lp were 1.31cm h-1 and 10.05, respectively and the permeability and partition coefficient (K) of Lipo-Fd were 1.28cm h-1 and 7.62, respectively. Labisia pumila and Ficus deltoidea loaded liposomes showed better transdermal permeation compared to un-encapsulated Labisia pumila and Ficus deltoidea indicative of potential actives herbal cosmetic formulations.