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Chemical composition, antibacterial and α-glucosidase inhibitory activities of the essential oils of Neolitsea coccinea (lauraceae)

Jani, Nor Akmalazura and Mohd. Sirat, Hasnah and Ahmad, Farediah and Mohamad Ali, Nor Azah and Zainal, Muhd. Hafizi (2016) Chemical composition, antibacterial and α-glucosidase inhibitory activities of the essential oils of Neolitsea coccinea (lauraceae). Natural Product Communications, 11 (12). pp. 1899-1902. ISSN 1934-578X

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Abstract

The chemical composition, antibacterial and α-glucosidase inhibitory activities of the essential oils obtained from hydrodistillation of the fresh stem and leaf of Neolitsea coccinea B. C. Stone are reported for the first time. GC and GC-MS analysis revealed the presence of 42 volatile compounds from the stem and leaf oils, accounting for 84.9% and 90.4%, respectively of the identified components. The principle compounds in the stem oil were 5-cadinene (21.2%), 1-epi-cubenol (11.3%) and cyperotundone (10.7%), while the main compounds in the leaf oil were selin-11-en-4-α-ol (26.8%), bicyclogermacrene (12.6%), γ-eudesmol (7.1%), germacrene D (6.1%) and globulol (5.9%). The leaf oil demonstrated moderate to weak antibacterial activity towards Bacillus subtilis and Staphylococcus aureus with MIC values of 250 μg/mL and 500 μg/mL, respectively, whereas the stem oil possessed weak antibacterial activity against B. subtilis with a MIC value of 500 μg/mL. The stem and leaf oils showed significant α-glucosidase inhibitory activity with IC50 values of 32.2 ± 0.8 μg/mL and 70.9 ± 1.1 μg/mL, respectively

Item Type:Article
Uncontrolled Keywords:1 epicubenol, alpha glucosidase, bicyclogermacrene, cyperotundone, delta cadinene, essential oil, gamma eudesmol, germacrene, globulol, plant medicinal product, selin 11 en 4 alpha ol, unclassified drug, antibacterial activity, Article, Bacillus subtilis, biochemical composition, controlled study, drug determination, enzyme activity, hydrodistillation, IC50, Lauraceae, mass fragmentography, minimum inhibitory concentration, Neolitsea coccinea, nonhuman, phytochemistry, plant leaf, plant stem, Staphylococcus aureus
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:74617
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:29 Nov 2017 23:58
Last Modified:29 Nov 2017 23:58

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