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Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation

Jantan, Ibrahim and Raweh, Salwa M and Sirat, Hasnah Mohd and Jamil, Shajarahtunnur and Mohd Yassin, Y.H and Jalil, Juriyati and Jamal, Jamia Azdina (2008) Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. Phytomedicine, 15 (4). pp. 306-309. ISSN 0944-7113

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Official URL: http://dx.doi.org/10.1016/j.phymed.2007.08.002


Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC50 values of less than 84 μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC50 values of 37.5, 60.9 and 45.7 μM, respectively.

Item Type:Article
Uncontrolled Keywords:Antiplatelet aggregation, human whole blood, curcumin, xanthorrhizol, arachidonic acid
Subjects:Q Science > QD Chemistry
ID Code:7432
Deposited By: Maznira Sylvia Azra Mansor
Deposited On:05 Jan 2009 01:15
Last Modified:05 Jan 2009 01:15

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