Selvakumaran, Suguna and Muhamad, Ida Idayu and Abd. Razak, Saiful Izwan (2016) Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of pore forming agents. Carbohydrate Polymers, 135 . pp. 207-214. ISSN 0144-8617
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Abstract
Floating hydrogels were prepared from kappa carrageenan containing CaCO3 and NaHCO3 as pore forming agents. The effects of CaCO3 and NaHCO3 on hydrogel characterizations were investigated and compared. Amoxicillin trihydrate was used as a model drug. Characterizations of the hydrogels were carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM). As pore forming agents concentration increases, the porosity (%) and floating properties increased. NaHCO3 incorporated hydrogels showed higher porosity with shorter floating lag time (FLT) than CaCO3. Hydrogel which contained CaCO3 exhibited better gel stability over the control and NaHCO3 containing gel. Incorporation of CaCO3 into kappa carrageenan hydrogel showed smoother surface gels compared to those produced with NaHCO3. CaCO3 also showed higher drug entrapment efficiency and sustained drug release profile than NaHCO3. The results of these studies showed that, CaCO3 is an effective pore forming agents in κC hydrogels preparation as compare to NaHCO3. Thus, CaCO3 can be an excellent pore forming agent for an effective floating drug delivery system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Calcium carbonate, Drug products, Fourier transform infrared spectroscopy, Porosity, Scanning electron microscopy, Sodium bicarbonate, X ray diffraction, Drug entrapment, Effective pores, Field emission scanning electron microscopes, Floating drug delivery systems, Floating property, Kappa carrageenan, Pore-forming agents, Sustained drug release, Hydrogels, amoxicillin, antiinfective agent, bicarbonate, calcium carbonate, carrageenan, hydrogel, chemistry, drug delivery system, drug release, hydrogel, infrared spectroscopy, porosity, scanning electron microscopy, X ray diffraction, Amoxicillin, Anti-Bacterial Agents, Calcium Carbonate, Carrageenan, Drug Delivery Systems, Drug Liberation, Hydrogels, Microscopy, Electron, Scanning, Porosity, Sodium Bicarbonate, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction |
| Subjects: | T Technology > TP Chemical technology |
| Divisions: | Chemical Engineering |
| ID Code: | 74237 |
| Deposited By: | Siti Nor Hashidah Zakaria |
| Deposited On: | 28 Nov 2017 07:42 |
| Last Modified: | 28 Nov 2017 07:42 |
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