Wan Salleh, Wan Mohd. Nuzul Hakimi and Ahmad, Farediah and Yen, Khong Heng and Zulkifli, Razauden Mohamed (2016) Chemical composition and biological activities of essential oil of Beilschmiedia pulverulenta. Pharmaceutical Biology, 54 (2). pp. 322-330. ISSN 1388-0209
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Abstract
The ethnopharmacological study of Beilschmiedia indicates that several species are used for the treatment of various ailments.Objective: This is the first study of the chemical composition of Beilschmiedia pulverulenta Kosterm (Lauraceae) essential oil and its antioxidant, antimicrobial, antityrosinase, anti-inflammatory, and anticholinesterase activities.Materials and methods: The antioxidant activities were evaluated by β-carotene, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric-reducing antioxidant power (FRAP), and phenolic content at different concentrations. The antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi were revealed by disk diffusion and microdilution. The antityrosinase and anti-inflammatory activities were assayed against mushroom tyrosinase and lipoxygenase enzymes. The anticholinesterase activity was analyzed using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.Results: Forty-two components were detected in B. pulverulenta oil with eugenol (45.3%) being the major component. The oil phenolic content and the FRAP were 660.1 mg gallic acid/g and 604.0 mg ascorbic acid/g, respectively. The oil gave an IC50 value of 94.5 μg/mL and an inhibition of 93.9% in DPPH and β-carotene, respectively. The antimicrobial activity showed that the oil had strong activity against all Gram-positive bacteria with an minimum inhibitory concentration (MIC) value each of 62.5 μg/mL and moderate against all fungi with MIC and minimum bactericidal concentration (MBC) values each of 125 μg/mL. The oil showed significant antityrosinase and anti-inflammatory activities with 67.6 and 62.5% inhibition, respectively. In addition, the oil had moderate AChE (56.5%) and BChE (48.2%) activities.Discussion and conclusion: The results show that the oil could potentially be used for nutraceutical industries, food manufactures, and therapeutic agents against various diseases such as inflammation and rheumatism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | alpha amorphene, alpha calacorene, alpha cubebene, alpha farnesene, alpha muurolene, alpha selinene, alpha ylangene, ar curcumene, aromadendrene, beta selinene, cadina 1,4 diene, caryophyllene, chemical compound, cis calamenene, copaene, delta cadinene, dihydro aromadendrene, dihydro eugenol, dihydro eugenol acetate, essential oil, eugenol, eugenol acetate, gamma gurjunene, germacrene B, humulene, iso longifolene, jasmone, longifolene, nerolidol, unclassified drug, unindexed drug, 2,2-diphenyl-1-picrylhydrazyl, antiinfective agent, antiinflammatory agent, antioxidant, biphenyl derivative, cholinesterase inhibitor, essential oil, eugenol, monophenol monooxygenase, phenol derivative, picric acid, antiinflammatory activity, antimicrobial activity, antioxidant activity, antityrosinase activity, Article, Aspergillus niger, assay, Bacillus subtilis, Beilschmiedia pulverulenta, biological activity, broth dilution, Candida albicans, chemical composition, cholinesterase inhibition, disk diffusion, DPPH radical scavenging assay, Enterococcus faecalis, Escherichia coli, ferric areducing antioxidant power, IC50, inhibition kinetics, Klebsiella pneumoniae, Lauraceae, minimum bactericidal concentration, minimum inhibitory concentration, mushroom, nonhuman, Pseudomonas aeruginosa, Saccharomyces cerevisiae, Staphylococcus aureus, antagonists and inhibitors, chemistry, drug effects, ethnopharmacology, fungus, Gram negative bacterium, Gram positive bacterium, isolation and purification, Lauraceae, microbial sensitivity test, Anti-Infective Agents, Anti-Inflammatory Agents, Antioxidants, Biphenyl Compounds, Cholinesterase Inhibitors, Ethnopharmacology, Eugenol, Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria, Lauraceae, Microbial Sensitivity Tests, Monophenol Monooxygenase, Oils, Volatile, Phenols, Picrates |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Science |
| ID Code: | 73930 |
| Deposited By: | Fahmi Moksen |
| Deposited On: | 22 Nov 2017 12:07 |
| Last Modified: | 22 Nov 2017 12:07 |
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