Salleh, W.M.N.H.W. and Ahmad, F. and Yen, K.H. and Zulkifli, R.M. and Sarker, S.D. (2016) Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities. Phytochemistry Letters, 15 . pp. 168-173. ISSN 1874-3900
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Abstract
Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 μM. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 μM, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antiinflammatory agent, antioxidant, ascorbic acid, beta sitostenone, betulin, cholinesterase inhibitor, cyclooxygenase 2, galantamine, indometacin, kunstlerone, madangone a, madangone b, neolignan, nitric oxide, sitosterol, tumor necrosis factor alpha, unclassified drug, vanillic acid, vanillin, acetylcholinesterase inhibitory activity, antiinflammatory activity, antioxidant activity, Article, bark, Beilschmiedia madang, carbon nuclear magnetic resonance, controlled study, DPPH radical scavenging assay, drug activity, drug structure, enzyme activity, heteronuclear multiple bond correlation, heteronuclear multiple quantum coherence, high resolution electrospray ionization mass spectrometry, IC50, infrared spectroscopy, mass spectrometry, nonhuman, nuclear Overhauser effect, optical rotation, plant stem, priority journal, proton nuclear magnetic resonance |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Science |
| ID Code: | 73826 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 18 Nov 2017 07:54 |
| Last Modified: | 18 Nov 2017 07:54 |
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