Universiti Teknologi Malaysia Institutional Repository

A model of the mechanical degradation of foam replicated scaffolds

Sulong, Mohd. Ayub and Belova, I. V. and Boccaccini, A. R. and Murch, G. E. and Fiedler, T. (2016) A model of the mechanical degradation of foam replicated scaffolds. Journal of Materials Science, 51 (8). pp. 3824-3835. ISSN 0022-2461

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Tissue engineering scaffolds are implants that actively support tissue growth whilst providing mechanical support. For optimum functionality, they are designed to slowly dissolve in vivo so that no foreign material remains permanently implanted inside the body. The current study uses a simple degradation model that estimates the change of scaffold geometry due to surface erosion. This model is applied on scaffolds that have been manufactured using the foam replication method. In order to capture their complex geometry, micro-computed tomography scans of samples are obtained. Their change in geometry and degradation of mechanical properties is evaluated using computational analysis. The present investigation found that the mechanical properties such as the quasi-elastic gradient, 0.2 % offset yield stress and the plateau stress are decreased systematically over a 10-week period of immersion time. Deformation analysis on the titania foam scaffold is performed by means of the deformed model obtained from finite element calculations.

Item Type:Article
Uncontrolled Keywords:Biomechanics, Computational geometry, Computerized tomography, Geometry, Mechanical properties, Scaffolds (biology), Stresses, Tissue, Tissue engineering, Yield stress, Complex geometries, Computational analysis, Deformation analysis, Degradation of mechanical properties, Mechanical degradation, Mechanical support, Microcomputed tomography, Tissue engineering scaffold, Finite element method
Subjects:T Technology > TJ Mechanical engineering and machinery
Divisions:Mechanical Engineering
ID Code:72745
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:27 Nov 2017 09:02
Last Modified:27 Nov 2017 09:02

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