Salleh, W. M. N. H. W. and Ahmad, F. and Khong, H. Y. and Zulkifli, R. M. and Chen, J. J. and Nahar, L. and Wansi, J. D. and Sarker, S. D. (2016) Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra. Phytochemistry Letters, 16 . pp. 192-196. ISSN 1874-3900
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Abstract
Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 24 methylenelanosta 7,9 diene 3beta 15 alpha diol, acetylcholinesterase, alkaloid derivative, antiinflammatory agent, ascorbic acid, beilschglabrine A, beilschglabrine B, enzyme inhibitor, galantamine, lipoxygenase, lupeol, phenanthrene derivative, quercetin, taraxerol, unclassified drug, antiinflammatory activity, Article, bark, Beilschmiedia glabra, controlled study, DPPH radical scavenging assay, drug identification, drug isolation, enzyme inhibition, Lauraceae, nonhuman, nuclear Overhauser effect, priority journal, proton nuclear magnetic resonance |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Science |
| ID Code: | 72504 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 27 Nov 2017 00:30 |
| Last Modified: | 27 Nov 2017 00:30 |
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