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Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley

Aminudin, Nurul Iman and Ahmad, Farediah and Taher, Muhammad and Mohamed Zulkifli, Razauden (2016) Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley. Records of Natural Products, 10 (5). pp. 649-653. ISSN 1307-6167

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Abstract

This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli. Phytochemical investigations of the bark extract yielded isoapetalic acid (1), apetalic acid (2), 6-hydroxy-2-methoxyxanthone (3) and ent-epicatechin (4). Meanwhile, betulinic acid (5), protocatechuic acid (6) and amentoflavone (7) were isolated from the leave extract. Isoapetalic acid (1) and apetalic acid (2) exhibited cytotoxic activities towards both cancer cell lines and both Gram-positive bacteria. Compounds (3-7) were inactive or showed moderate activities towards cytotoxic and antibacterial tests. This study presents the first report on the phytochemicals investigation from C. ferrugineum and all compounds are reported for the first time from this source.

Item Type:Article
Additional Information:Available in SCOPUS
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:69122
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:01 Nov 2017 05:02
Last Modified:23 Nov 2017 06:02

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