Universiti Teknologi Malaysia Institutional Repository

Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement

Salma, Abdullah Binsilm and Rad, Maryam Alsadat and Ahmad, Mohd. Ridzuan (2016) Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement. Applied Sciences, 6 (12). p. 339. ISSN 2076-3417

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Official URL: http://www.mdpi.com/2076-3417/6/12/339

Abstract

In this research, a finite element study on a nanoneedle-microfluidic system for single cell temperature measurement is presented. The nanoneedle design and electrical and mechanical characterization are analyzed, in which tungsten is used as the sensing material. A rectangular shaped sensor with a gap of 10.8 µm showed to give the same current density distribution within the nanoneedle, and a 90 nm2 cross-sectional area showed to cause minimum damage to the cell. Furthermore, the current showed to have a positive temperature coefficient of resistance (TCR) with an increase in the temperature, and the nanoneedle showed to be able to resist ramp force up to 22.5 μN before failure. Electrical measurement on yeast cell showed that the nanoneedle was independent of the cell conductivity. The nanoneedle proved to be able to measure temperature with a current difference of 50 nA and a resolution of 0.02 °C in 10 ms. A Y-shaped microchannel was proposed and the microchannel cross-sectional area was optimized to be 63 μm2 and a flow rate of 24.6 pL/min allowed successful cell penetration causing minimal damage to the cell.

Item Type:Article
Additional Information:RADIS System Ref No:PB/2016/07670
Uncontrolled Keywords:microfluidics, nanoneedle
Subjects:T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:Advanced Informatics School
ID Code:68249
Deposited By: Widya Wahid
Deposited On:30 Nov 2017 02:15
Last Modified:30 Nov 2017 02:15

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