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The effect justicia gendarussa ethanolic extract enhance bone matrix deposition in in vitro study

Supparmaniam, Kavita and Mohd. Bohari, Siti Pauliena (2015) The effect justicia gendarussa ethanolic extract enhance bone matrix deposition in in vitro study. In: International Conference on Natural Products 2015, 24-25 March, 2015, Johor Bahru, Malaysia.

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Official URL: http://science.utm.my/icnp2015/

Abstract

Justicia gendarussa (Acanthaceae) or commonly known as Gendarussa has traditionally been used to treat bone fractures. Bone fracture is a clinical condition that need bone repair and new bone formation. To date, the mechanism of Justicia gendarussa acting in enhancing the bone mineralization has not been proven scientifically. The present study aimed to investigate the cytotoxicity and alkaline phosphatase (ALP) activity on osteoblast cells when treated with Justicia gendarussa ethanolic leaves extract. For cell viability, the result showed that IC50 value of the osteoblast cells was 89.1µg/ml. While, ALP assay is used as a biochemical marker for early detection of osteoblast mineralization. The highest amount of ALP activity was at the 37.5 µg/ml when compared to the control. From this study, it shows that Justicia gendarussa has potential in enhancing bone mineralization during the bone repair process.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:alkaline phosphatase (ALP), bone mineralization
Subjects:R Medicine > R Medicine (General)
Divisions:Biosciences and Medical Engineering
ID Code:63494
Deposited By: Fazli Masari
Deposited On:30 May 2017 05:00
Last Modified:30 May 2017 05:00

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