Mohd. Yunos, Nurul Hidayah and Hamdan, Halimaton and Lee, Siew Ling (2008) Nano-Enabled Drug Delivery System for Piperine. In: Asia Nanotech Camp 2008 Symposium, 20 Feb. 2008, Nagoya University, Japan.
The feasibility of silica matrix as an oral drug delivery carrier for natural product is explored. Silica aerogel and silica xerogel were produced via sol-gel process using rice husk ash as silica source. A local drug, piperine was loaded onto/into silica aerogel and xerogel via wet impregnation and physical mixing methods. The drug loaded silica matrices were characterized using FTIR and UV-Vis spectroscopies in order to show no degradation of piperine occurred during the loading procedure. Characterizations with BET, XRD, and FESEM demonstrated the successful loading of piperine into/onto silica matrices. XRD results show the amorphization of piperine crystals after the loading process with silica aerogel,indicating the increment in the specific surface area of the drug. These results were then confirmed by BET surface area analysis. UV-Vis spectroscopy analysis revealed that the amount of piperine loaded was higher in silica aerogel (drug/carrier ~80 wt%)than silica xerogel (~65 wt%), suggesting that silica aerogel is a better drug carrier than silica xerogel. This could be due to the larger pore and higher surface area of silica aerogel compared to silica xerogel. Silica aerogel was constituted as a potential drug delivery device with high drug loading.
|Item Type:||Conference or Workshop Item (Paper)|
|Uncontrolled Keywords:||Keywords: Silica Aerogel; Sol-gel; Drug delivery system; Nanomaterials|
|Subjects:||Q Science > QD Chemistry|
|Deposited By:||Dr Siew Ling Lee|
|Deposited On:||08 Oct 2008 04:20|
|Last Modified:||26 Oct 2010 08:56|
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