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Comparative cytotoxicity of glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells

Basar, Norazah and Oridupa, Olayinka Ayoutunde and Ritchie, Kenneth J. and Nahar, Lutfun and M. Osman, Nashwa Mostafa and Stafford, Angela and Kushiev, Habibjon and Kan, Asuman and Sarker, Satyajit D. (2015) Comparative cytotoxicity of glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells. In: International Conference on Natural Products, 23-24 Mar, 2015, Johor Bahru, Johor.

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Abstract

Glycyrrhiza glabra L. (Fabaceae), commonly known as ‘liquorice’, is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, anti-inflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepato- and cardio-protective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G. glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide (MTT) cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of G. glabra.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:skin disorder, cardiovascular diseases
Subjects:Q Science > QP Physiology
Divisions:Science
ID Code:62192
Deposited By: Widya Wahid
Deposited On:14 May 2017 00:46
Last Modified:03 Aug 2017 04:33

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