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Production of cellulose acetate dialysis membrane, suitable for separation of BSA solution

Idris, Ani and Lee, Kuan Yet (2004) Production of cellulose acetate dialysis membrane, suitable for separation of BSA solution. In: Regional Symposium on Chemical Engineering 2004, December 1-3, 2004, The Grand Hotel, Bangkok, Thailand.

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Abstract

Flat sheet dialysis membranes were casted by the phase inversion method using cellulose acetate as the polymer and acetic acid as the solvent. Modification agents such as polyethylene glycol 400 and non-solvent swelling agent, distillated water are added. Five different formulations were used, and the performances of the membranes were then tested using 1 mg/mL bovine serum albumin (BSA) solution with molecular weight of 30,000 kDa. It is found that membrane with higher cellulose acetate content gives higher BSA rejection rate. The formulation consisting of 20 %wt cellulose acetate, 60 %wt acetic acid, 10 %wt PEG 400 and 10 %wt distillated water exhibits the best result with a BSA rejection rate of 96.19 %. However, all the five membranes are capable to separate the BSA solution with the rejection rates of above 90.00 %. This proved that dialysis membrane fabricated from cellulose acetate is biocompatible and promising, to retain macromolecules during the dialysis process. These results were in good agreement theoretically where dialysis membranes need to provide very effective clearance of small solutes such as urea and creative from blood stream, while macromolecules such as globulin, hemoglobin which has similar molecular weight to BSA will be retained in the blood stream.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Bovine serum albumin (BSA), cellulose acetate, dialysis membrane, rejection rate
Subjects:T Technology > T Technology (General)
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:6143
Deposited By: Norhani Jusoh
Deposited On:26 Aug 2008 10:43
Last Modified:01 Jun 2010 15:39

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