Formulation and characterization of [6]-gingerol loaded nanostructured lipid carrier (NLC)

Abstract

Nanostructured lipid carrier (NLC) is the blend of solid lipid, liquid lipid and suitable surfactant for the purpose of encapsulated poorly water soluble drugs. [6]-gingerol is the main bioactive compound in Zingiber officinale, widely known as ginger in Malaysia. Zingiber officinale extract has been discovered to have anti-oxidant, anti-inflammatory, and anti-microbial effects to human body. The aim of this study is to develop NLC formulation for [6]-gingerol and to estimate the potential of NLC as a delivery system for these water insoluble drugs. In this work, the preparation of ginger oil loaded onto nanostructured lipid carrier (GO-NLC) was done by using ultrasonication method. The GO-NLCs were assessed by evaluating the morphology and its entrapment efficiency. The morphological study was performed by using Zetasizer Nano S and the entrapment efficiency analysis of NLC was performed using HPLC by detecting [6]-gingerol as active biomarker. The average particle size for GO-NLCs ranged from size 100 to 250 nm and the average encapsulation efficiency was 92.7± 3.03%.Based on analysis, it is proved that nanostructured lipid carriers has high potential to be nanocarriers for [6]-gingerol.