Ficus deltoidea extract protects hacat keratinocytes from UVB irradiation-induced inflammation

Abstract

Ficus deltoidea from the Moraceae family is a popular medicinal herb in Malaysia. It possesses strong antioxidant and anti-inflammatory properties. In the present study, the anti-inflammatory effects of F deltoidea extract on UVB-irradiated HaCaT Keratinocytes were investigated HaCaT Keratinocytes were UVB-iradiated (12,5 mj/cm ) and were treated with 0.05,0.08 or 0.1% of F. deltoidea extract. Cell viability following UVB irradiation was sigfi cantly higher in the groups treated with the F. deltoidea extract at doses of 0.05,0.0B or 0.1% than in control group with UVB irradiation only. TNF-o, lL-1a, IL-6. and cydooxygenase (COX-2) play pnmary roles In the inflammation process upon UV eradiation and are known to be stimulated by UVB irradiatwn. Treatment with the F. deltoidea extract dramatically inhibited the UV-induced TNF-o. Il-1a. IL-6, and COX-2 expression. These results suggest that the f. deltoidea extract may exert a protective effect against UVB-induced skin inflammation.