Mohamad Rosdi, Mohamad Norisham and Nik Mat Daud, Nik Nurul Najihah and Mohamed Zulkifli, Razauden and Ya'akob, Harisun (2015) Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells. Journal Of Applied Pharmaceutical Science, 5 (5). pp. 45-48. ISSN 2231-3354
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Official URL: http://dx.doi.org/10.7324/JAPS.2015.50508 Publish...
Abstract
Annona muricata Linn has been reported to contain valuable bioactive compounds known as Annonaceous acetogenins.Theselong chain fatty acids were widely discussed for its potential in promoting anticancer and anti-proliferative activity in various cancer cell lines. However, little study has been done on A. muricata effect in pancreatic cancer cells. In this study, the viability of Capan-1 after treatment with A. muricata extracts was determined by using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The results displayed that only hexane and commercialized extract inhibited cell proliferation in a concentration-dependent manner with IC<inf>25</inf> varied ~7.8-8μg/ml and ~0.9-1.0μg/ml respectively. The data demonstrate that A. muricata hexane and commercialized extracts induced mild cytotoxicity in pancreatic cancer cells (Capan-1).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | annona muricata linn, capan-1, graviola |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Biosciences and Medical Engineering |
| ID Code: | 58200 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 04 Dec 2016 04:07 |
| Last Modified: | 05 Oct 2021 08:12 |
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